Knockout rat models mimicking human atherosclerosis created by Cpf1-mediated gene targeting

The rat is a time-honored traditional experimental model animal, but its use is limited due to the difficulty of genetic modification. Although engineered endonucleases enable us to manipulate the rat genome, it is not known whether the newly identified endonuclease Cpf1 system is applicable to rats...

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Detalles Bibliográficos
Autores principales: Lee, Jong Geol, Ha, Chang Hoon, Yoon, Bohyun, Cheong, Seung-A., Kim, Globinna, Lee, Doo Jae, Woo, Dong-Cheol, Kim, Young-Hak, Nam, Sang-Yoon, Lee, Sang-wook, Sung, Young Hoon, Baek, In-Jeoung
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6385241/
https://www.ncbi.nlm.nih.gov/pubmed/30796231
http://dx.doi.org/10.1038/s41598-019-38732-2

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6385241/
https://www.ncbi.nlm.nih.gov/pubmed/30796231
http://dx.doi.org/10.1038/s41598-019-38732-2

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