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Knockout rat models mimicking human atherosclerosis created by Cpf1-mediated gene targeting
The rat is a time-honored traditional experimental model animal, but its use is limited due to the difficulty of genetic modification. Although engineered endonucleases enable us to manipulate the rat genome, it is not known whether the newly identified endonuclease Cpf1 system is applicable to rats...
| Autores principales: | , , , , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Nature Publishing Group UK
2019
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6385241/ https://www.ncbi.nlm.nih.gov/pubmed/30796231 http://dx.doi.org/10.1038/s41598-019-38732-2 |