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Irreversible electroporation reverses resistance to immune checkpoint blockade in pancreatic cancer
Immunotherapy has only limited efficacy against pancreatic ductal adenocarcinoma (PDAC) due to the presence of an immunosuppressive tumor-associated stroma. Here, we demonstrate an effective modulation of that stroma by irreversible electroporation (IRE), a local ablation technique that has received...
Autores principales: | Zhao, Jun, Wen, Xiaofei, Tian, Li, Li, Tingting, Xu, Chunyu, Wen, Xiaoxia, Melancon, Marites P., Gupta, Sanjay, Shen, Baozhong, Peng, Weiyi, Li, Chun |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6385305/ https://www.ncbi.nlm.nih.gov/pubmed/30796212 http://dx.doi.org/10.1038/s41467-019-08782-1 |
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