Exploration of inositol 1,4,5-trisphosphate (IP(3)) regulated dynamics of N-terminal domain of IP(3) receptor reveals early phase molecular events during receptor activation

Inositol 1, 4, 5-trisphosphate (IP(3)) binding at the N-terminus (NT) of IP(3) receptor (IP(3)R) allosterically triggers the opening of a Ca(2+)-conducting pore located ~100 Å away from the IP(3)-binding core (IBC). However, the precise mechanism of IP(3) binding and correlated domain dynamics in th...

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Detalles Bibliográficos
Autores principales: Chandran, Aneesh, Chee, Xavier, Prole, David L., Rahman, Taufiq
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6385359/
https://www.ncbi.nlm.nih.gov/pubmed/30792485
http://dx.doi.org/10.1038/s41598-019-39301-3

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6385359/
https://www.ncbi.nlm.nih.gov/pubmed/30792485
http://dx.doi.org/10.1038/s41598-019-39301-3

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