Cargando…
Exploration of inositol 1,4,5-trisphosphate (IP(3)) regulated dynamics of N-terminal domain of IP(3) receptor reveals early phase molecular events during receptor activation
Inositol 1, 4, 5-trisphosphate (IP(3)) binding at the N-terminus (NT) of IP(3) receptor (IP(3)R) allosterically triggers the opening of a Ca(2+)-conducting pore located ~100 Å away from the IP(3)-binding core (IBC). However, the precise mechanism of IP(3) binding and correlated domain dynamics in th...
| Autores principales: | , , , |
|---|---|
| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Nature Publishing Group UK
2019
|
| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6385359/ https://www.ncbi.nlm.nih.gov/pubmed/30792485 http://dx.doi.org/10.1038/s41598-019-39301-3 |