Zoledronic acid inhibits the growth of cancer stem cell derived from cervical cancer cell by attenuating their stemness phenotype and inducing apoptosis and cell cycle arrest through the Erk1/2 and Akt pathways

BACKGROUND: Zoledronic acid is the most potent osteoclast inhibitor and is widely used for advanced cancer patients with bone metastasis, but its role on cancer stem cells (CSCs) remains unclear. In the present study, we aimed to identify the stemness phenotypic characteristics of CSCs derived from...

Descripción completa

Detalles Bibliográficos
Autores principales: Wang, Li, Liu, Yanyang, Zhou, Yueling, Wang, Jiantao, Tu, Li, Sun, Zhen, Wang, Xiujie, Luo, Feng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2019
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6385443/
https://www.ncbi.nlm.nih.gov/pubmed/30791957
http://dx.doi.org/10.1186/s13046-019-1109-z

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6385443/
https://www.ncbi.nlm.nih.gov/pubmed/30791957
http://dx.doi.org/10.1186/s13046-019-1109-z

Ejemplares similares