A Novel Role of Prolidase in Cocaine-Mediated Breach in the Barrier of Brain Microvascular Endothelial Cells

Cocaine use is associated with breach in the blood brain barrier (BBB) and increased HIV-1 neuro-invasion. We show that the cellular enzyme “Prolidase” plays a key role in cocaine-induced disruption of the BBB. We established a barrier model to mimic the BBB by culturing human brain microvascular en...

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Detalles Bibliográficos
Autores principales: Ysrayl, Binah baht, Balasubramaniam, Muthukumar, Albert, Ife, Villalta, Fernando, Pandhare, Jui, Dash, Chandravanu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6385491/
https://www.ncbi.nlm.nih.gov/pubmed/30796241
http://dx.doi.org/10.1038/s41598-018-37495-6

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6385491/
https://www.ncbi.nlm.nih.gov/pubmed/30796241
http://dx.doi.org/10.1038/s41598-018-37495-6

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