Cargando…

Single Cell Profiling Reveals PTEN Overexpression in Influenza-Specific B cells in Aging HIV-infected individuals on Anti-retroviral Therapy

Memory B cells (MBC) respond to secondary antigen challenge to protect against infection and to boost immunity following vaccinations. Despite effective treatment, chronic HIV infection disturbs MBCs by reducing numbers and altering functionality due to hyper-activation and increased apoptosis leadi...

Descripción completa

Detalles Bibliográficos
Autores principales:	de Armas, Lesley R., Pallikkuth, Suresh, Pan, Li, Rinaldi, Stefano, Cotugno, Nicola, Andrews, Sarah, Pahwa, Rajendra, McDermott, Adrian B., Palma, Paolo, Pahwa, Savita
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2019
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6385500/ https://www.ncbi.nlm.nih.gov/pubmed/30792481 http://dx.doi.org/10.1038/s41598-019-38906-y

Ejemplares similares

Paediatric HIV infection in the ‘omics era: defining transcriptional signatures of viral control and vaccine responses
por: Cotugno, Nicola, et al.
Publicado: (2015)

T Follicular Helper Cells and B Cell Dysfunction in Aging and HIV-1 Infection
por: Pallikkuth, Suresh, et al.
Publicado: (2017)

Dysfunctional peripheral T follicular helper cells dominate in people with impaired influenza vaccine responses: Results from the FLORAH study
por: Pallikkuth, Suresh, et al.
Publicado: (2019)

Perturbation of B Cell Gene Expression Persists in HIV-Infected Children Despite Effective Antiretroviral Therapy and Predicts H1N1 Response
por: Cotugno, Nicola, et al.
Publicado: (2017)

Immunological age prediction in HIV-infected, ART-treated individuals
por: de Armas, Lesley R., et al.
Publicado: (2021)

B-cell immunity and vaccine induced antibody protection reveal the inefficacy of current vaccination schedule in infants with perinatal HIV-infection in Mozambique, Africa
por: Cotugno, Nicola, et al.
Publicado: (2023)

Paradoxical aging in HIV: immune senescence of B Cells is most prominent in young age
por: Rinaldi, Stefano, et al.
Publicado: (2017)

Association of Flu specific and SARS-CoV-2 specific CD4 T cell responses in SARS-CoV-2 infected asymptomatic heath care workers
por: Pallikkuth, Suresh, et al.
Publicado: (2021)

Artificial Intelligence Applied to in vitro Gene Expression Testing (IVIGET) to Predict Trivalent Inactivated Influenza Vaccine Immunogenicity in HIV Infected Children
por: Cotugno, Nicola, et al.
Publicado: (2020)

Viral Response among Early Treated HIV Perinatally Infected Infants: Description of a Cohort in Southern Mozambique
por: Lain, Maria Grazia, et al.
Publicado: (2022)

T cell immune discriminants of HIV reservoir size in a pediatric cohort of perinatally infected individuals
por: Rinaldi, Stefano, et al.
Publicado: (2021)

The Effect of JAK1/2 Inhibitors on HIV Reservoir Using Primary Lymphoid Cell Model of HIV Latency
por: de Armas, Lesley R., et al.
Publicado: (2021)

IL-21 enhances influenza vaccine responses in aged macaques with suppressed SIV infection
por: Kvistad, Daniel, et al.
Publicado: (2021)

Metabolic phenotype of B cells from young and elderly HIV individuals
por: Frasca, Daniela, et al.
Publicado: (2021)

HIV-1 reservoir evolution in infants infected with clade C from Mozambique
por: Koofhethile, Catherine K., et al.
Publicado: (2023)

Serosurvey of Immunity to Monkeypox (Mpox) Virus Antigens in People Living with HIV in South Florida
por: Kupritz, Jonah, et al.
Publicado: (2023)

Age Associated Microbiome and Microbial Metabolites Modulation and Its Association With Systemic Inflammation in a Rhesus Macaque Model
por: Pallikkuth, Suresh, et al.
Publicado: (2021)

Cardiac morbidity in HIV infection is associated with checkpoint inhibitor LAG-3 on CD4 T cells
por: Pallikkuth, Suresh, et al.
Publicado: (2018)

Impaired Antibody Response to Influenza Vaccine in HIV-Infected and Uninfected Aging Women Is Associated with Immune Activation and Inflammation
por: Parmigiani, Anita, et al.
Publicado: (2013)

IL‐21‐IgFc immunotherapy alters transcriptional landscape of lymph node cells leading to enhanced flu vaccine response in aging and SIV infection
por: Pallikkuth, Suresh, et al.
Publicado: (2023)

S-nitrosoglutathione modulates CXCR4 and ICOS expression
por: Yamamoto, Yoshihiko, et al.
Publicado: (2006)

Immune correlates of cardiovascular co-morbidity in HIV infected participants from South India
por: Kausalya, Bagavathi, et al.
Publicado: (2022)

A delayed fractionated dose RTS,S AS01 vaccine regimen mediates protection via improved T follicular helper and B cell responses
por: Pallikkuth, Suresh, et al.
Publicado: (2020)

Peripheral T follicular helper cells from H1N1/09 vaccine nonresponders fail to induce antigen-specific antibody production in vitro
por: Parmigiani, A, et al.
Publicado: (2012)

Compromised steady‐state germinal center activity with age in nonhuman primates
por: Shankwitz, Kimberly, et al.
Publicado: (2019)

Permissive omicron breakthrough infections in individuals with binding or neutralizing antibodies to ancestral SARS-CoV-2
por: Williams, Erin, et al.
Publicado: (2022)

Double Jeopardy: Methamphetamine Use and HIV as Risk Factors for COVID-19
por: Carrico, Adam W., et al.
Publicado: (2020)

953. Frailty Among People Living with HIV In Miami, A Cross Sectional Pilot Study
por: Salguero, Douglas, et al.
Publicado: (2020)

Pretransplant Levels of C-Reactive Protein, Soluble TNF Receptor-1, and CD38+HLADR+ CD8 T Cells Predict Risk of Allograft Rejection in HIV+ Kidney Transplant Recipients
por: Camargo, Jose F., et al.
Publicado: (2019)

P16-47. Interleukin (IL)-21 induces cytolytic molecule perforin in CD4 and CD8 T cells without CD4 activation in chronically SIV infected rhesus macaques
por: Pahwa, S, et al.
Publicado: (2009)

Opioids exacerbate inflammation in people with well-controlled HIV
por: Dang, Christine M., et al.
Publicado: (2023)

Transcriptional and Immunologic Correlates of Response to Pandemic Influenza Vaccine in Aviremic, HIV-Infected Children
por: de Armas, Lesley R., et al.
Publicado: (2021)

Immune Activation in HIV-Infected Aging Women on Antiretrovirals—Implications for Age-Associated Comorbidities: A Cross-Sectional Pilot Study
por: Alcaide, Maria L., et al.
Publicado: (2013)

Long-Term Engraftment of Human Natural T Regulatory Cells in NOD/SCID IL2rγc(null) Mice by Expression of Human IL-2
por: Abraham, Sojan, et al.
Publicado: (2012)

HIV and HCV augments inflammatory responses through increased TREM-1 expression and signaling in Kupffer and Myeloid cells
por: Hyun, Jinhee, et al.
Publicado: (2019)

Sexual Minority Stress and Cellular Aging in Methamphetamine-Using Sexual Minority Men With Treated HIV
por: Ghanooni, Delaram, et al.
Publicado: (2022)

Size of HIV‐1 reservoir is associated with telomere shortening and immunosenescence in early‐treated European children with perinatally acquired HIV‐1
por: Dalzini, Annalisa, et al.
Publicado: (2021)

Early ART initiation during infancy preserves natural killer cells in young European adolescents living with HIV (CARMA cohort)
por: Doria, Margherita, et al.
Publicado: (2021)

Maintenance of Intestinal Th17 Cells and Reduced Microbial Translocation in SIV-infected Rhesus Macaques Treated with Interleukin (IL)-21
por: Pallikkuth, Suresh, et al.
Publicado: (2013)

Recombinant IL-21 induces perforin and granzyme B in total and virus specific CD8 Tcells in acute and early stages of SIV infection in rhesus macaques
por: Pallikkuth, S, et al.
Publicado: (2012)

Cannot write session to /tmp/vufind_sessions/sess_ft4im9l5jj5u2v6h4qri560grp