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Loss of Platelet Endothelial Cell Adhesion Molecule-1 (PECAM-1) in the Diabetic Retina: Role of Matrix Metalloproteinases

PURPOSE: To test the hypothesis that high glucose and matrix metalloproteinases (MMPs) contribute to the diabetes-induced loss of platelet endothelial cell adhesion molecule-1 (PECAM-1) in the retinal microvasculature. METHODS: PECAM-1 and MMP protein, activity, and interactions with PECAM-1 were as...

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Detalles Bibliográficos
Autores principales: Eshaq, Randa S., Harris, Norman R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Association for Research in Vision and Ophthalmology 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6385619/
https://www.ncbi.nlm.nih.gov/pubmed/30793207
http://dx.doi.org/10.1167/iovs.18-25068