PDK4 Augments ER–Mitochondria Contact to Dampen Skeletal Muscle Insulin Signaling During Obesity

Mitochondria-associated endoplasmic reticulum membrane (MAM) is a structural link between mitochondria and endoplasmic reticulum (ER). MAM regulates Ca(2+) transport from the ER to mitochondria via an IP3R1-GRP75-VDAC1 complex–dependent mechanism. Excessive MAM formation may cause mitochondrial Ca(2...

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Detalles Bibliográficos
Autores principales: Thoudam, Themis, Ha, Chae-Myeong, Leem, Jaechan, Chanda, Dipanjan, Park, Jong-Seok, Kim, Hyo-Jeong, Jeon, Jae-Han, Choi, Yeon-Kyung, Liangpunsakul, Suthat, Huh, Yang Hoon, Kwon, Tae-Hwan, Park, Keun-Gyu, Harris, Robert A., Park, Kyu-Sang, Rhee, Hyun-Woo, Lee, In-Kyu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Diabetes Association 2019
Materias:
Signal Transduction
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6385748/
https://www.ncbi.nlm.nih.gov/pubmed/30523025
http://dx.doi.org/10.2337/db18-0363

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6385748/
https://www.ncbi.nlm.nih.gov/pubmed/30523025
http://dx.doi.org/10.2337/db18-0363

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