Macrocyclisation of small peptides enabled by oxetane incorporation

Cyclic peptides are an important source of new drugs but are challenging to produce synthetically. We show that head-to-tail peptide macrocyclisations are greatly improved, as measured by isolated yields, reaction rates and product distribution, by substitution of one of the backbone amide C[double...

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Detalles Bibliográficos
Autores principales: Roesner, Stefan, Saunders, George J., Wilkening, Ina, Jayawant, Eleanor, Geden, Joanna V., Kerby, Paul, Dixon, Ann M., Notman, Rebecca, Shipman, Michael
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Royal Society of Chemistry 2019
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6385813/
https://www.ncbi.nlm.nih.gov/pubmed/30881675
http://dx.doi.org/10.1039/c8sc05474f

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6385813/
https://www.ncbi.nlm.nih.gov/pubmed/30881675
http://dx.doi.org/10.1039/c8sc05474f

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