Structural insights reveal a recognition feature for tailoring hydrocarbon stapled-peptides against the eukaryotic translation initiation factor 4E protein

Stapled-peptides have emerged as an exciting class of molecules which can modulate protein–protein interactions. We have used a structure-guided approach to rationally develop a set of hydrocarbon stapled-peptides with high binding affinities and residence times against the oncogenic eukaryotic tran...

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Detalles Bibliográficos
Autores principales: Lama, Dilraj, Liberatore, Anne-Marie, Frosi, Yuri, Nakhle, Jessica, Tsomaia, Natia, Bashir, Tarig, Lane, David P., Brown, Christopher J., Verma, Chandra S., Auvin, Serge
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Royal Society of Chemistry 2019
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6385854/
https://www.ncbi.nlm.nih.gov/pubmed/30881679
http://dx.doi.org/10.1039/c8sc03759k

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6385854/
https://www.ncbi.nlm.nih.gov/pubmed/30881679
http://dx.doi.org/10.1039/c8sc03759k

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