Integrated Assessment of the Clinical Performance of GalNAc(3)-Conjugated 2′-O-Methoxyethyl Chimeric Antisense Oligonucleotides: I. Human Volunteer Experience

Advances in medicinal chemistry have produced new chemical classes of antisense oligonucleotides (ASOs) with enhanced therapeutic properties. Conjugation of the triantennary N-acetylgalactosamine (GalNAc(3)) moiety to the extensively characterized phosphorothioate (PS)-modified 2′-O-methoxyethyl (2′...

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Detalles Bibliográficos
Autores principales: Crooke, Stanley T., Baker, Brenda F., Xia, Shuting, Yu, Rosie Z., Viney, Nicholas J., Wang, Yanfeng, Tsimikas, Sotirios, Geary, Richard S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Mary Ann Liebert, Inc., publishers 2019
Materias:
Original Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6386089/
https://www.ncbi.nlm.nih.gov/pubmed/30570431
http://dx.doi.org/10.1089/nat.2018.0753

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6386089/
https://www.ncbi.nlm.nih.gov/pubmed/30570431
http://dx.doi.org/10.1089/nat.2018.0753

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