Targeting mTOR and Src restricts hepatocellular carcinoma growth in a novel murine liver cancer model

Liver cancer is a poor prognosis cancer with limited treatment options. To develop a new therapeutic approach, we derived HCC cells from a known model of murine hepatocellular carcinoma (HCC). We treated adiponectin (APN) knock-out mice with the carcinogen diethylnitrosamine, and the resulting tumor...

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Detalles Bibliográficos
Autores principales: Walker, Sarah, Wankell, Miriam, Ho, Vikki, White, Rose, Deo, Nikita, Devine, Carol, Dewdney, Brittany, Bhathal, Prithi, Govaere, Olivier, Roskams, Tania, Qiao, Liang, George, Jacob, Hebbard, Lionel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2019
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6386388/
https://www.ncbi.nlm.nih.gov/pubmed/30794695
http://dx.doi.org/10.1371/journal.pone.0212860

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6386388/
https://www.ncbi.nlm.nih.gov/pubmed/30794695
http://dx.doi.org/10.1371/journal.pone.0212860

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