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Broad antifungal resistance mediated by RNAi-dependent epimutation in the basal human fungal pathogen Mucor circinelloides

Mucormycosis—an emergent, deadly fungal infection—is difficult to treat, in part because the causative species demonstrate broad clinical antifungal resistance. However, the mechanisms underlying drug resistance in these infections remain poorly understood. Our previous work demonstrated that one ma...

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Detalles Bibliográficos
Autores principales: Chang, Zanetta, Billmyre, R. Blake, Lee, Soo Chan, Heitman, Joseph
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6386414/
https://www.ncbi.nlm.nih.gov/pubmed/30742617
http://dx.doi.org/10.1371/journal.pgen.1007957