Canonical Wnt is inhibited by targeting one-carbon metabolism through methotrexate or methionine deprivation

The nutrient-sensing metabolite S-adenosylmethionine (SAM) controls one-carbon metabolism by donating methyl groups to biochemical building blocks, DNA, RNA, and protein. Our recent work uncovered a requirement for cytoplasmic arginine methylation during Wnt signaling through the activity of protein...

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Detalles Bibliográficos
Autores principales: Albrecht, Lauren V., Bui, Maggie H., De Robertis, Edward M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2019
Materias:
PNAS Plus
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6386671/
https://www.ncbi.nlm.nih.gov/pubmed/30679275
http://dx.doi.org/10.1073/pnas.1820161116

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6386671/
https://www.ncbi.nlm.nih.gov/pubmed/30679275
http://dx.doi.org/10.1073/pnas.1820161116

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