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Canonical Wnt is inhibited by targeting one-carbon metabolism through methotrexate or methionine deprivation
The nutrient-sensing metabolite S-adenosylmethionine (SAM) controls one-carbon metabolism by donating methyl groups to biochemical building blocks, DNA, RNA, and protein. Our recent work uncovered a requirement for cytoplasmic arginine methylation during Wnt signaling through the activity of protein...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
National Academy of Sciences
2019
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6386671/ https://www.ncbi.nlm.nih.gov/pubmed/30679275 http://dx.doi.org/10.1073/pnas.1820161116 |