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Structural basis for antiarrhythmic drug interactions with the human cardiac sodium channel
The human voltage-gated sodium channel, hNa(V)1.5, is responsible for the rapid upstroke of the cardiac action potential and is target for antiarrhythmic therapy. Despite the clinical relevance of hNa(V)1.5-targeting drugs, structure-based molecular mechanisms of promising or problematic drugs have...
| Autores principales: | , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
National Academy of Sciences
2019
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6386684/ https://www.ncbi.nlm.nih.gov/pubmed/30728299 http://dx.doi.org/10.1073/pnas.1817446116 |