Increased gene copy number of DEFA1/DEFA3 worsens sepsis by inducing endothelial pyroptosis

Sepsis claims an estimated 30 million episodes and 6 million deaths per year, and treatment options are rather limited. Human neutrophil peptides 1–3 (HNP1–3) are the most abundant neutrophil granule proteins but their neutrophil content varies because of unusually extensive gene copy number polymor...

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Detalles Bibliográficos
Autores principales: Chen, QiXing, Yang, Yang, Hou, JinChao, Shu, Qiang, Yin, YiXuan, Fu, WeiTao, Han, Feng, Hou, TingJun, Zeng, CongLi, Nemeth, Elizabeta, Linzmeier, Rose, Ganz, Tomas, Fang, XiangMing
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2019
Materias:
PNAS Plus
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6386704/
https://www.ncbi.nlm.nih.gov/pubmed/30718392
http://dx.doi.org/10.1073/pnas.1812947116

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6386704/
https://www.ncbi.nlm.nih.gov/pubmed/30718392
http://dx.doi.org/10.1073/pnas.1812947116

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