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Molecular basis for AU-rich element recognition and dimerization by the HuR C-terminal RRM
Human antigen R (HuR) is a key regulator of cellular mRNAs containing adenylate/uridylate–rich elements (AU-rich elements; AREs). These are a major class of cis elements within 3′ untranslated regions, targeting these mRNAs for rapid degradation. HuR contains three RNA recognition motifs (RRMs): a t...
Autores principales: | Ripin, Nina, Boudet, Julien, Duszczyk, Malgorzata M., Hinniger, Alexandra, Faller, Michael, Krepl, Miroslav, Gadi, Abhilash, Schneider, Robert J., Šponer, Jiří, Meisner-Kober, Nicole C., Allain, Frédéric H.-T. |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
National Academy of Sciences
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6386705/ https://www.ncbi.nlm.nih.gov/pubmed/30718402 http://dx.doi.org/10.1073/pnas.1808696116 |
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