Structural insights into FTO’s catalytic mechanism for the demethylation of multiple RNA substrates

FTO demethylates internal N(6)-methyladenosine (m(6)A) and N(6),2′-O-dimethyladenosine (m(6)A(m); at the cap +1 position) in mRNA, m(6)A and m(6)A(m) in snRNA, and N(1)-methyladenosine (m(1)A) in tRNA in vivo, and in vitro evidence supports that it can also demethylate N(6)-methyldeoxyadenosine (6mA...

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Detalles Bibliográficos
Autores principales: Zhang, Xiao, Wei, Lian-Huan, Wang, Yuxin, Xiao, Yu, Liu, Jun, Zhang, Wei, Yan, Ning, Amu, Gubu, Tang, Xinjing, Zhang, Liang, Jia, Guifang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2019
Materias:
Biological Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6386707/
https://www.ncbi.nlm.nih.gov/pubmed/30718435
http://dx.doi.org/10.1073/pnas.1820574116

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6386707/
https://www.ncbi.nlm.nih.gov/pubmed/30718435
http://dx.doi.org/10.1073/pnas.1820574116

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