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Structural insights into FTO’s catalytic mechanism for the demethylation of multiple RNA substrates
FTO demethylates internal N(6)-methyladenosine (m(6)A) and N(6),2′-O-dimethyladenosine (m(6)A(m); at the cap +1 position) in mRNA, m(6)A and m(6)A(m) in snRNA, and N(1)-methyladenosine (m(1)A) in tRNA in vivo, and in vitro evidence supports that it can also demethylate N(6)-methyldeoxyadenosine (6mA...
| Autores principales: | , , , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
National Academy of Sciences
2019
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6386707/ https://www.ncbi.nlm.nih.gov/pubmed/30718435 http://dx.doi.org/10.1073/pnas.1820574116 |