IL-7R-mediated signaling in T-cell acute lymphoblastic leukemia: An update

Interleukin 7 (IL-7) and its receptor (IL-7R, a heterodimer of IL-7Rα and γc) are essential for normal lymphoid development. In their absence, severe combined immunodeficiency occurs. By contrast, excessive IL-7/IL-7R-mediated signaling can drive lymphoid leukemia development, disease acceleration a...

Descripción completa

Detalles Bibliográficos
Autores principales: Oliveira, Mariana L., Akkapeddi, Padma, Ribeiro, Daniel, Melão, Alice, Barata, João T.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6386770/
https://www.ncbi.nlm.nih.gov/pubmed/30249539
http://dx.doi.org/10.1016/j.jbior.2018.09.012

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6386770/
https://www.ncbi.nlm.nih.gov/pubmed/30249539
http://dx.doi.org/10.1016/j.jbior.2018.09.012

Ejemplares similares