Cargando…

IL-7R-mediated signaling in T-cell acute lymphoblastic leukemia: An update

Interleukin 7 (IL-7) and its receptor (IL-7R, a heterodimer of IL-7Rα and γc) are essential for normal lymphoid development. In their absence, severe combined immunodeficiency occurs. By contrast, excessive IL-7/IL-7R-mediated signaling can drive lymphoid leukemia development, disease acceleration a...

Descripción completa

Detalles Bibliográficos
Autores principales:	Oliveira, Mariana L., Akkapeddi, Padma, Ribeiro, Daniel, Melão, Alice, Barata, João T.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier 2019
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6386770/ https://www.ncbi.nlm.nih.gov/pubmed/30249539 http://dx.doi.org/10.1016/j.jbior.2018.09.012

Ejemplares similares

A fully human anti-IL-7Rα antibody promotes antitumor activity against T-cell acute lymphoblastic leukemia
por: Akkapeddi, Padma, et al.
Publicado: (2019)

NRARP displays either pro- or anti-tumoral roles in T-cell acute lymphoblastic leukemia depending on Notch and Wnt signaling
por: Pinto, Inês, et al.
Publicado: (2019)

Mutant IL7R collaborates with MYC to induce T-cell acute lymphoblastic leukemia
por: Oliveira, Mariana L., et al.
Publicado: (2022)

microRNAs regulate TAL1 expression in T-cell acute lymphoblastic leukemia
por: Correia, Nádia C., et al.
Publicado: (2016)

P339: DEVELOPMENT OF ANTI-IL-7RΑ ANTIBODIES AS A TARGETED THERAPY FOR T-CELL ACUTE LYMPHOBLASTIC LEUKEMIA
por: Duque, Mafalda, et al.
Publicado: (2023)

Overexpression of wild-type IL-7Rα promotes T-cell acute lymphoblastic leukemia/lymphoma
por: Silva, Ana, et al.
Publicado: (2021)

Clinical-Grade Peptide-Based Inhibition of CK2 Blocks Viability and Proliferation of T-ALL Cells and Counteracts IL-7 Stimulation and Stromal Support
por: Perera, Yasser, et al.
Publicado: (2020)

Gain-of-function mutations in interleukin-7 receptor-α (IL7R) in childhood acute lymphoblastic leukemias
por: Shochat, Chen, et al.
Publicado: (2011)

Gain-of-function mutations in interleukin-7 receptor-α (IL7R) in childhood acute lymphoblastic leukemias
por: Shochat, Chen, et al.
Publicado: (2011)

MiR-146b negatively regulates migration and delays progression of T-cell acute lymphoblastic leukemia
por: Correia, Nádia C., et al.
Publicado: (2016)

Activation of PI3K Is Indispensable for Interleukin 7–mediated Viability, Proliferation, Glucose Use, and Growth of T Cell Acute Lymphoblastic Leukemia Cells
por: Barata, Joao T., et al.
Publicado: (2004)

Interleukin-7 receptor α mutational activation can initiate precursor B-cell acute lymphoblastic leukemia
por: Almeida, Afonso R. M., et al.
Publicado: (2021)

Coexistence of EZH2, NOTCH1, IL7R, and PHF6 Mutations in Adult T-cell Acute Lymphoblastic Leukemia
por: Zhou, Xilian, et al.
Publicado: (2017)

Inhibiting Janus Kinase 1 and BCL-2 to treat T cell acute lymphoblastic leukemia with IL7-Rα mutations
por: Senkevitch, Emilee, et al.
Publicado: (2018)

Recent updates for antibody therapy for acute lymphoblastic leukemia
por: Li, Le, et al.
Publicado: (2020)

New Challenges in Targeting Signaling Pathways in Acute Lymphoblastic Leukemia by NGS Approaches: An Update
por: Montaño, Adrián, et al.
Publicado: (2018)

Downregulation of Renal MRPs Transporters in Acute Lymphoblastic Leukemia Mediated by the IL-6/STAT3/PXR Signaling Pathway
por: Zhou, Yue, et al.
Publicado: (2021)

Timing of Tocilizumab Administration Under the Guidance of IL-6 in CAR-T Therapy for R/R Acute Lymphoblastic Leukemia
por: Zhang, Yinqiang, et al.
Publicado: (2022)

MEK and PI3K-AKT inhibitors synergistically block activated IL7 receptor signaling in T-cell acute lymphoblastic leukemia
por: Canté-Barrett, K, et al.
Publicado: (2016)

Synergism between IL7R and CXCR4 drives BCR-ABL induced transformation in Philadelphia chromosome-positive acute lymphoblastic leukemia
por: Abdelrasoul, Hend, et al.
Publicado: (2020)

Childhood B-acute lymphoblastic leukemia: a genetic update
por: Woo, Jennifer S, et al.
Publicado: (2014)

Acute lymphoblastic leukemia: a comprehensive review and 2017 update
por: Terwilliger, T, et al.
Publicado: (2017)

P1379: DEVELOPMENT OF A GENE THERAPY CELL DEATH-INDUCING SYSTEM REGULATED BY MICRORNAS FOR T-CELL ACUTE LYMPHOBLASTIC LEUKEMIA.
por: Duque, Mafalda, et al.
Publicado: (2023)

Integrin signaling is critical for myeloid-mediated support of T-cell acute lymphoblastic leukemia
por: Lyu, Aram, et al.
Publicado: (2023)

Monobodies as tool biologics for accelerating target validation and druggable site discovery
por: Akkapeddi, Padma, et al.
Publicado: (2021)

Therapeutic Targeting of mTOR in T-Cell Acute Lymphoblastic Leukemia: An Update
por: Evangelisti, Camilla, et al.
Publicado: (2018)

IL-7 Receptor Mutations and Steroid Resistance in Pediatric T cell Acute Lymphoblastic Leukemia: A Genome Sequencing Study
por: Li, Yunlei, et al.
Publicado: (2016)

P319: IL7-RECEPTOR EXPRESSION IS FREQUENT IN T-CELL ACUTE LYMPHOBLASTIC LEUKEMIA AND PREDICTS SENSITIVITY TO JAK-INHIBITION
por: Courtois, Lucien, et al.
Publicado: (2023)

Update on the Use of l-Asparaginase in Infants and Adolescent Patients with Acute Lymphoblastic Leukemia
por: Andrade, Augusto F, et al.
Publicado: (2014)

An Update on Clinical Trials and Potential Therapeutic Strategies in T-Cell Acute Lymphoblastic Leukemia
por: Patel, Janisha, et al.
Publicado: (2023)

Updates in KMT2A Gene Rearrangement in Pediatric Acute Lymphoblastic Leukemia
por: Górecki, Mateusz, et al.
Publicado: (2023)

A novel anti-human IL-1R7 antibody reduces IL-18-mediated inflammatory signaling
por: Li, Suzhao, et al.
Publicado: (2021)

Aberrant Signaling Pathways in T-Cell Acute Lymphoblastic Leukemia
por: Bongiovanni, Deborah, et al.
Publicado: (2017)

Targeting miR-126 in Ph+ acute lymphoblastic leukemia
por: Qiao, Junjing, et al.
Publicado: (2023)

PRL3 enhances T cell acute lymphoblastic leukemia growth through suppressing T cell signaling pathways and apoptosis
por: Garcia, E.G., et al.
Publicado: (2020)

miR-101 Represses T-Cell Acute Lymphoblastic Leukemia by Targeting CXCR7/STAT3 Axis
por: Yang, Xue-Yi, et al.
Publicado: (2019)

Co-existence of IL7R high and SH2B3 low expression distinguishes a novel high-risk acute lymphoblastic leukemia with Ikaros dysfunction
por: Ge, Zheng, et al.
Publicado: (2016)

JAK/STAT pathway inhibition overcomes IL7-induced glucocorticoid resistance in a subset of human T-cell acute lymphoblastic leukemias
por: Delgado-Martin, C, et al.
Publicado: (2017)

Expression of CXCL8 (IL-8) in the Pathogenesis of T-Cell Acute Lymphoblastic Leukemia Patients
por: Pandey, Sandeep, et al.
Publicado: (2023)

A Novel t(5;7)(q31;q21)/CDK6::IL3 in Immature T-cell Acute Lymphoblastic Leukemia With IL3 Expression and Eosinophilia
por: Pierini, Valentina, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_k22geue0cu30ga1hb9de97nl78