Catabolism of Fibromodulin in Developmental Rudiment and Pathologic Articular Cartilage Demonstrates Novel Roles for MMP-13 and ADAMTS-4 in C-terminal Processing of SLRPs

Background: Cartilage regeneration requires a balance of anabolic and catabolic processes. Aim: To examine the susceptibility of fibromodulin (FMOD) and lumican (LUM) to degradation by MMP-13, ADAMTS-4 and ADAMTS-5, the three major degradative proteinases in articular cartilage, in cartilage develop...

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Detalles Bibliográficos
Autores principales: Shu, Cindy C, Flannery, Carl R, Little, Christopher B, Melrose, James
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6386837/
https://www.ncbi.nlm.nih.gov/pubmed/30700002
http://dx.doi.org/10.3390/ijms20030579

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6386837/
https://www.ncbi.nlm.nih.gov/pubmed/30700002
http://dx.doi.org/10.3390/ijms20030579

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