Structural Perspective on Revealing and Altering Molecular Functions of Genetic Variants Linked with Diseases

Structural information of biological macromolecules is crucial and necessary to deliver predictions about the effects of mutations—whether polymorphic or deleterious (i.e., disease causing), wherein, thermodynamic parameters, namely, folding and binding free energies potentially serve as effective b...

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Detalles Bibliográficos
Autores principales: Peng, Yunhui, Alexov, Emil, Basu, Sankar
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6386852/
https://www.ncbi.nlm.nih.gov/pubmed/30696058
http://dx.doi.org/10.3390/ijms20030548

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6386852/
https://www.ncbi.nlm.nih.gov/pubmed/30696058
http://dx.doi.org/10.3390/ijms20030548

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