Vanillic Acid Suppresses HIF-1α Expression via Inhibition of mTOR/p70S6K/4E-BP1 and Raf/MEK/ERK Pathways in Human Colon Cancer HCT116 Cells

Hypoxia-inducible factor 1 (HIF-1) plays a pivotal role in tumor adaptation to microenvironmental hypoxia, and it also exerts important roles in angiogenesis and tumor development. Vanillic acid is a dietary phenolic compound reported to exhibit anticancer properties. However, the mechanisms by whic...

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Detalles Bibliográficos
Autores principales: Gong, Jingli, Zhou, Shengxue, Yang, Shihai
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6387037/
https://www.ncbi.nlm.nih.gov/pubmed/30678221
http://dx.doi.org/10.3390/ijms20030465

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6387037/
https://www.ncbi.nlm.nih.gov/pubmed/30678221
http://dx.doi.org/10.3390/ijms20030465

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