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Lipid–Protein Interactions in Niemann–Pick Type C Disease: Insights from Molecular Modeling
The accumulation of lipids in the late endosomes and lysosomes of Niemann–Pick type C disease (NPCD) cells is a consequence of the dysfunction of one protein (usually NPC1) but induces dysfunction in many proteins. We used molecular docking to propose (a) that NPC1 exports not just cholesterol, but...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
MDPI
2019
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6387118/ https://www.ncbi.nlm.nih.gov/pubmed/30736449 http://dx.doi.org/10.3390/ijms20030717 |