Lipid–Protein Interactions in Niemann–Pick Type C Disease: Insights from Molecular Modeling

The accumulation of lipids in the late endosomes and lysosomes of Niemann–Pick type C disease (NPCD) cells is a consequence of the dysfunction of one protein (usually NPC1) but induces dysfunction in many proteins. We used molecular docking to propose (a) that NPC1 exports not just cholesterol, but...

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Detalles Bibliográficos
Autores principales: Wheeler, Simon, Schmid, Ralf, Sillence, Dan J
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6387118/
https://www.ncbi.nlm.nih.gov/pubmed/30736449
http://dx.doi.org/10.3390/ijms20030717