Cargando…

Association of the MDM2 SNP285 and SNP309 Genetic Variants with the Risk, Age at Onset and Prognosis of Breast Cancer in Central European Women: A Hospital-Based Case-Control Study

SNP309T>G (rs2279744) and SNP285G>C (rs117039649) in the MDM2 promoter are thought to have opposite effects on the binding of transcription factor SP1 (specificity protein 1), and consequently on MDM2 expression, p53 levels, cancer risk, age at onset, and prognosis. Here, we genotyped SNP309 a...

Descripción completa

Detalles Bibliográficos
Autores principales:	Miedl, Heidi, Lebhard, Jürgen, Ehart, Lisa, Schreiber, Martin
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2019
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6387136/ https://www.ncbi.nlm.nih.gov/pubmed/30691044 http://dx.doi.org/10.3390/ijms20030509

Ejemplares similares

MDM2 promoter SNP285 and SNP309; phylogeny and impact on cancer risk
por: Knappskog, Stian, et al.
Publicado: (2011)

MDM2 SNP309 and SNP285 Act as Negative Prognostic Markers for Non-small Cell Lung Cancer Adenocarcinoma Patients
por: Deben, Christophe, et al.
Publicado: (2017)

Effect of the MDM2 promoter polymorphisms SNP309T>G and SNP285G>C on the risk of ovarian cancer in BRCA1 mutation carriers
por: Bjørnslett, Merete, et al.
Publicado: (2012)

Prognostic Impact of the MDM2(SNP309) Allele in Leukemia and Lymphoma
por: Post, Sean M., et al.
Publicado: (2010)

MDM2 SNP309 polymorphism is associated with colorectal cancer risk
por: Wang, Weizhi, et al.
Publicado: (2014)

Correlations between MDM2 gene SNP309 Polymorphism and Susceptibility to Leukemia
por: Ou, Wen-Bin
Publicado: (2015)

Population distribution and ancestry of the cancer protective MDM2 SNP285 (rs117039649)
por: Knappskog, Stian, et al.
Publicado: (2014)

Association of the MDM2 SNP285 Polymorphism with Cancer Susceptibility: A Meta-Analysis
por: Wang, Ping, et al.
Publicado: (2016)

MDM2 gene SNP309 T/G and p53 gene SNP72 G/C do not influence diffuse large B-cell non-Hodgkin lymphoma onset or survival in central European Caucasians
por: Bittenbring, Joerg, et al.
Publicado: (2008)

Early onset lung cancer, cigarette smoking and the SNP309 of the murine double minute-2 (MDM2) gene
por: Mittelstrass, Kirstin, et al.
Publicado: (2008)

MDM2 SNP309, gene-gene interaction, and tumor susceptibility: an updated meta-analysis
por: Wan, Yan, et al.
Publicado: (2011)

An Updated Meta-Analysis on the Association of MDM2 SNP309 Polymorphism with Colorectal Cancer Risk
por: Qin, Xue, et al.
Publicado: (2013)

Rapid Detection of SNP (c.309T>G) in the MDM2 Gene by the Duplex SmartAmp Method
por: Enokida, Yasuaki, et al.
Publicado: (2013)

MDM2 SNP309 rs2279744 Polymorphism and Gastric Cancer Risk: A Meta-Analysis
por: Ma, Yong, et al.
Publicado: (2013)

Impact of TP53 Codon 72 and MDM2 SNP 309 Polymorphisms in Pancreatic Ductal Adenocarcinoma
por: Hori, Yasuki, et al.
Publicado: (2015)

A cohort study on the association of MDM2 SNP309 with lung cancer risk in Bangladeshi population
por: Reza, Hasan Al, et al.
Publicado: (2020)

Homozygous G/G variant of SNP309 in the human MDM2 gene is associated with earlier tumor onset in Caucasian female renal cell carcinoma patients
por: Stoehr, C G, et al.
Publicado: (2016)

Mdm2-SNP309 polymorphism in prostate cancer: no evidence for association with increased risk or histopathological tumour characteristics
por: Stoehr, R, et al.
Publicado: (2008)

Influence of the MDM2 single nucleotide polymorphism SNP309 on tumour development in BRCA1 mutation carriers
por: Copson, Ellen R, et al.
Publicado: (2006)

MDM2 SNP309 promoter polymorphism and p53 mutations in urinary bladder carcinoma stage T1
por: Olsson, Hans, et al.
Publicado: (2013)

MDM2 SNP309 polymorphism contributes to endometrial cancer susceptibility: evidence from a meta-analysis
por: Peng, Qiliu, et al.
Publicado: (2013)

Association of MDM2 SNP309 and TP53 Arg72Pro polymorphisms with risk of endometrial cancer
por: YONEDA, TOMOKO, et al.
Publicado: (2013)

Correction: Impact of TP53 Codon 72 and MDM2 SNP 309 Polymorphisms in Pancreatic Ductal Adenocarcinoma
Publicado: (2015)

Association between MDM2 SNP309 and endometrial cancer risk: A PRISMA-compliant meta-analysis
por: Zou, Xinwei, et al.
Publicado: (2018)

Association of MDM2 SNP309 Variation with Lung Cancer Risk: Evidence from 7196 Cases and 8456 Controls
por: Zhuo, Wenlei, et al.
Publicado: (2012)

MDM2 SNP309 polymorphism is associated with lung cancer risk in women: A meta-analysis using METAGEN
por: HE, WENWU, et al.
Publicado: (2012)

Association of PIK3CA and MDM2 SNP309 with Cervical Squamous Cell Carcinoma in a Philippine Population
por: Tantengco, Ourlad Alzeus G, et al.
Publicado: (2019)

MDM2 SNP309 is associated with high grade node positive breast tumours and is in linkage disequilibrium with a novel MDM2 intron 1 polymorphism
por: Paulin, Fiona EM, et al.
Publicado: (2008)

Is MDM2 SNP309 Variation a Risk Factor for Head and Neck Carcinoma?: An Updated Meta-Analysis Based on 11,552 Individuals
por: Zhuo, Xianlu, et al.
Publicado: (2016)

A case‐control study on the SNP309T → G and 40‐bp Del1518 of the MDM2 gene and a systematic review for MDM2 polymorphisms in the patients with breast cancer
por: Jalilvand, Amin, et al.
Publicado: (2020)

Association between MDM2 SNP309 T>G polymorphism and the risk of bladder cancer: new data in a Chinese population and an updated meta-analysis
por: Xie, Linguo, et al.
Publicado: (2015)

Association between MDM2 SNP309, p53 Arg72Pro, and hepatocellular carcinoma risk: A MOOSE-compliant meta-analysis
por: Duan, Xiaohua, et al.
Publicado: (2017)

Effect of MDM2 SNP309 and p53 codon 72 polymorphisms on lung cancer risk and survival among non-smoking Chinese women in Singapore
por: Chua, Hui Wan, et al.
Publicado: (2010)

AB265. Association between MDM2 SNP309T>G polymorphism and the risk of bladder cancer: new data in Chinese population and an update meta-analysis
por: Xie, Linguo, et al.
Publicado: (2016)

The 40bp Indel Polymorphism rs150550023 in the MDM2 Promoter is Associated with Intriguing Shifts in Gene Expression in the p53-MDM2 Regulatory Hub
por: Miedl, Heidi, et al.
Publicado: (2020)

Combined effects of single nucleotide polymorphisms TP53 R72P and MDM2 SNP309, and p53 expression on survival of breast cancer patients
por: Schmidt, Marjanka K, et al.
Publicado: (2009)

Homozygous mdm2 SNP309 cancer cells with compromised transcriptional elongation at p53 target genes are sensitive to induction of p53-independent cell death
por: Rosso, Melissa, et al.
Publicado: (2015)

Murine Double-Minute 2 Homolog Single Nucleotide Polymorphisms 285 and 309 in Cervical Carcinogenesis
por: Roszak, Andrzej, et al.
Publicado: (2015)

Results based on 124 cases of breast cancer and 97 controls from Taiwan suggest that the single nucleotide polymorphism (SNP309) in the MDM2 gene promoter is associated with earlier onset and increased risk of breast cancer
por: Sun, Ying-Fang, et al.
Publicado: (2009)

Murine Double Minute 2 SNP T309G Polymorphism and Urinary Tract Cancer Risk: A Meta-Analysis
por: Ding, Hui, et al.
Publicado: (2016)

Cannot write session to /tmp/vufind_sessions/sess_6d0a3mk4k2p42dprjfa6gpvutp