Emergence of synaptic and cognitive impairment in a mature-onset APP mouse model of Alzheimer’s disease

The synaptic changes underlying the onset of cognitive impairment in Alzheimer’s disease (AD) are poorly understood. In contrast to the well documented inhibition of long-term potentiation (LTP) in CA3-CA1 synapses by acute Aβ application in adult neurons from rodents, young amyloid precursor protei...

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Detalles Bibliográficos
Autores principales: Sri, Sarmi, Pegasiou, Chrysia-Maria, Cave, Chantal Abbigail, Hough, Katie, Wood, Natalie, Gomez-Nicola, Diego, Deinhardt, Katrin, Bannerman, David, Perry, V. Hugh, Vargas-Caballero, Mariana
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2019
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6387506/
https://www.ncbi.nlm.nih.gov/pubmed/30795807
http://dx.doi.org/10.1186/s40478-019-0670-1

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6387506/
https://www.ncbi.nlm.nih.gov/pubmed/30795807
http://dx.doi.org/10.1186/s40478-019-0670-1

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