Cargando…

Emergence of synaptic and cognitive impairment in a mature-onset APP mouse model of Alzheimer’s disease

The synaptic changes underlying the onset of cognitive impairment in Alzheimer’s disease (AD) are poorly understood. In contrast to the well documented inhibition of long-term potentiation (LTP) in CA3-CA1 synapses by acute Aβ application in adult neurons from rodents, young amyloid precursor protei...

Descripción completa

Detalles Bibliográficos
Autores principales:	Sri, Sarmi, Pegasiou, Chrysia-Maria, Cave, Chantal Abbigail, Hough, Katie, Wood, Natalie, Gomez-Nicola, Diego, Deinhardt, Katrin, Bannerman, David, Perry, V. Hugh, Vargas-Caballero, Mariana
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2019
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6387506/ https://www.ncbi.nlm.nih.gov/pubmed/30795807 http://dx.doi.org/10.1186/s40478-019-0670-1

Ejemplares similares

A primate-specific short GluN2A-NMDA receptor isoform is expressed in the human brain
por: Warming, Hannah, et al.
Publicado: (2019)

Wild-Type, but Not Mutant N296H, Human Tau Restores Aβ-Mediated Inhibition of LTP in Tau(−/−) mice
por: Vargas-Caballero, Mariana, et al.
Publicado: (2017)

Pharmacological targeting of CSF1R inhibits microglial proliferation and prevents the progression of Alzheimer’s-like pathology
por: Olmos-Alonso, Adrian, et al.
Publicado: (2016)

First effects of rising amyloid-β in transgenic mouse brain: synaptic transmission and gene expression
por: Cummings, Damian M., et al.
Publicado: (2015)

Age-related changes in tau and autophagy in human brain in the absence of neurodegeneration
por: Chatterjee, Shreyasi, et al.
Publicado: (2023)

The role of microglia in synaptic stripping and synaptic degeneration: a revised perspective
por: Hugh Perry, V, et al.
Publicado: (2010)

Deciphering the role of APP in synaptic function
por: Zheng, Hui
Publicado: (2012)

A luminescence-based reporter to study tau secretion reveals overlapping mechanisms for the release of healthy and pathological tau
por: Lopez, Dianne Marquez, et al.
Publicado: (2023)

Behavioral deficits, early gliosis, dysmyelination and synaptic dysfunction in a mouse model of mucolipidosis IV
por: Grishchuk, Yulia, et al.
Publicado: (2014)

Brain Region Specific Pre-Synaptic and Post-Synaptic Degeneration Are Early Components of Neuropathology in Prion Disease
por: Šišková, Zuzana, et al.
Publicado: (2013)

Tetanus toxin is internalized by a sequential clathrin-dependent mechanism initiated within lipid microdomains and independent of epsin1
por: Deinhardt, Katrin, et al.
Publicado: (2006)

Excitability and Synaptic Alterations in the Cerebellum of APP/PS1 Mice
por: Hoxha, Eriola, et al.
Publicado: (2012)

Miniature Neurotransmission Regulates Drosophila Synaptic Structural Maturation
por: Choi, Ben Jiwon, et al.
Publicado: (2014)

Mitochondria and Synaptic Plasticity in the Mature and Aging Nervous System
por: Todorova, Vyara, et al.
Publicado: (2017)

A 5′ UTR GGN repeat controls localisation and translation of a potassium leak channel mRNA through G-quadruplex formation
por: Maltby, Connor J, et al.
Publicado: (2020)

Evaluation of posttraumatic stress disorder diagnosis and therapy on diurnal blood pressure patterns from 24-hour ambulatory blood pressure monitoring
por: Cave, Brandon, et al.
Publicado: (2019)

FANCJ helicase promotes DNA end resection by facilitating CtIP recruitment to DNA double-strand breaks
por: Nath, Sarmi, et al.
Publicado: (2020)

Autophagy-Mediated Synaptic Refinement and Auditory Neural Pruning Contribute to Ribbon Synaptic Maturity in the Developing Cochlea
por: Guo, Rui, et al.
Publicado: (2022)

Presynaptic APP levels and synaptic homeostasis are regulated by Akt phosphorylation of huntingtin
por: Bruyère, Julie, et al.
Publicado: (2020)

APP family member dimeric complexes are formed predominantly in synaptic compartments
por: Schilling, Sandra, et al.
Publicado: (2023)

CBP and SRF co-regulate dendritic growth and synaptic maturation
por: del Blanco, Beatriz, et al.
Publicado: (2019)

Oxytocin signaling is necessary for synaptic maturation of adult-born neurons
por: Pekarek, Brandon T., et al.
Publicado: (2022)

MIR137 schizophrenia-associated locus controls synaptic function by regulating synaptogenesis, synapse maturation and synaptic transmission
por: He, Enqi, et al.
Publicado: (2018)

Overexpression of Swedish mutant APP in aged astrocytes attenuates excitatory synaptic transmission
por: Katsurabayashi, Shutaro, et al.
Publicado: (2016)

CART treatment improves memory and synaptic structure in APP/PS1 mice
por: Jin, Jia-li, et al.
Publicado: (2015)

The two faces of synaptic failure in App(NL-G-F) knock-in mice
por: Latif-Hernandez, Amira, et al.
Publicado: (2020)

Altered dynamics of glymphatic flow in a mature-onset Tet-off APP mouse model of amyloidosis
por: Ben-Nejma, Inès R. H., et al.
Publicado: (2023)

Regulation of PPARα by APP in Alzheimer disease affects the pharmacological modulation of synaptic activity
por: Sáez-Orellana, Francisco, et al.
Publicado: (2021)

Fingolimod mitigates synaptic deficits and psychosis‐like behavior in APP/PSEN1 mice
por: Krivinko, Josh M., et al.
Publicado: (2022)

Role for a Novel Usher Protein Complex in Hair Cell Synaptic Maturation
por: Zallocchi, Marisa, et al.
Publicado: (2012)

Proteolytic maturation of α(2)δ controls the probability of synaptic vesicular release
por: Ferron, Laurent, et al.
Publicado: (2018)

APP Is Cleaved by Bace1 in Pre-Synaptic Vesicles and Establishes a Pre-Synaptic Interactome, via Its Intracellular Domain, with Molecular Complexes that Regulate Pre-Synaptic Vesicles Functions
por: Del Prete, Dolores, et al.
Publicado: (2014)

Impact of amyloid β aggregate maturation on antibody treatment in APP23 mice
por: Balakrishnan, Karthikeyan, et al.
Publicado: (2015)

Synaptic Changes in the Dentate Gyrus of APP/PS1 Transgenic Mice Revealed by Electron Microscopy
por: Alonso-Nanclares, Lidia, et al.
Publicado: (2013)

APP and APLP2 interact with the synaptic release machinery and facilitate transmitter release at hippocampal synapses
por: Fanutza, Tomas, et al.
Publicado: (2015)

Insulin-like growth factor 2 reverses memory and synaptic deficits in APP transgenic mice
por: Pascual-Lucas, Maria, et al.
Publicado: (2014)

Novel Insights into the Physiological Function of the APP (Gene) Family and Its Proteolytic Fragments in Synaptic Plasticity
por: Ludewig, Susann, et al.
Publicado: (2017)

Altered synaptic glutamate homeostasis contributes to cognitive decline in young APP/PSEN1 mice
por: Wilcox, J.M., et al.
Publicado: (2021)

Actin- and Dynamin-Dependent Maturation of Bulk Endocytosis Restores Neurotransmission following Synaptic Depletion
por: Nguyen, Tam H., et al.
Publicado: (2012)

Fragile X astrocytes induce developmental delays in dendrite maturation and synaptic protein expression
por: Jacobs, Shelley, et al.
Publicado: (2010)

Cannot write session to /tmp/vufind_sessions/sess_n1ifgjiqq9pr4bt1ghm9c7hrbn