Cargando…

MUC16 impacts tumor proliferation and migration through cytoplasmic translocation of P120-catenin in epithelial ovarian cancer cells: an original research

BACKGROUND: Epithelial ovarian cancer (EOC) remains one of the most lethal gynecologic cancers, and its pathogenetic mechanism remains unclear. Here we show that MUC16 promotes the translocation of p120-catenin (p120ctn) to the cytoplasm and consequently activates ras homolog (Rho) GTPases RhoA/Cdc4...

Descripción completa

Detalles Bibliográficos
Autores principales:	Chen, Xin, Li, Xiaoduan, Wang, Xinjing, Zhu, Qinyi, Wu, Xiaoli, Wang, Xipeng
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2019
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6387523/ https://www.ncbi.nlm.nih.gov/pubmed/30795761 http://dx.doi.org/10.1186/s12885-019-5371-4

Ejemplares similares

Identification of immune microenvironment subtypes that predicted the prognosis of patients with ovarian cancer
por: Wang, Xinjing, et al.
Publicado: (2021)

Suppression of endothelial cell migration by tumor associated macrophage-derived exosomes is reversed by epithelial ovarian cancer exosomal lncRNA
por: Wu, Quanfeng, et al.
Publicado: (2017)

The emerging roles and therapeutic potential of exosomes in epithelial ovarian cancer
por: Li, Xiaoduan, et al.
Publicado: (2017)

Stanniocalcin 1 promotes metastasis, lipid metabolism and cisplatin chemoresistance via the FOXC2/ITGB6 signaling axis in ovarian cancer
por: Lin, Feikai, et al.
Publicado: (2022)

Epithelial ovarian cancer-secreted exosomal miR-222-3p induces polarization of tumor-associated macrophages
por: Ying, Xiang, et al.
Publicado: (2016)

The lnc-CTSLP8 upregulates CTSL1 as a competitive endogenous RNA and promotes ovarian cancer metastasis
por: Wang, Xinjing, et al.
Publicado: (2021)

Long non-coding RNA CTSLP8 mediates ovarian cancer progression and chemotherapy resistance by modulating cellular glycolysis and regulating c-Myc expression through PKM2
por: Li, Xiaoduan, et al.
Publicado: (2021)

Differential distribution of tumor-associated macrophages and Treg/Th17 cells in the progression of malignant and benign epithelial ovarian tumors
por: Zhu, Qinyi, et al.
Publicado: (2017)

MUC1 regulates cyclin D1 gene expression through p120 catenin and β-catenin
por: Liu, X, et al.
Publicado: (2014)

Crosstalk between TEMs and endothelial cells modulates angiogenesis and metastasis via IGF1-IGF1R signalling in epithelial ovarian cancer
por: Wang, Xinjing, et al.
Publicado: (2017)

The expression of Duffy antigen receptor for chemokines by epithelial ovarian cancer decreases growth potential
por: Zhu, Qinyi, et al.
Publicado: (2017)

The Cytoplasmic Domain of MUC1 Induces Hyperplasia in the Mammary Gland and Correlates with Nuclear Accumulation of β-Catenin
por: Li, Yuan, et al.
Publicado: (2011)

Ovarian cancer: epigenetics, drug resistance, and progression
por: Xie, Weiwei, et al.
Publicado: (2021)

Diagnostic potential of nanoparticle aided assays for MUC16 and MUC1 glycovariants in ovarian cancer
por: Jain, Shruti, et al.
Publicado: (2022)

Single-cell analyses implicate ascites in remodeling the ecosystems of primary and metastatic tumors in ovarian cancer
por: Zheng, Xiaocui, et al.
Publicado: (2023)

Synapses are regulated by the cytoplasmic tyrosine kinase Fer in a pathway mediated by p120catenin, Fer, SHP-2, and β-catenin
por: Lee, Seung-Hye, et al.
Publicado: (2008)

Comparison of the Transmembrane Mucins MUC1 and MUC16 in Epithelial Barrier Function
por: Gipson, Ilene K., et al.
Publicado: (2014)

P120 regulates beta-catenin nuclear translocation through E-cadherin endocytosis in ventilator-induced lung injury
por: Gu, Changping, et al.
Publicado: (2016)

MUC16 stimulates neutrophils to an inflammatory and immunosuppressive phenotype in ovarian cancer
por: Wu, Yuliang, et al.
Publicado: (2023)

Polymorphisms of MUC16 (CA125) and MUC1 (CA15.3) in Relation to Ovarian Cancer Risk and Survival
por: Williams, Kristina A., et al.
Publicado: (2014)

Altered Localization of p120 Catenin in the Cytoplasm Rather than the Membrane Correlates with Poor Prognosis in Esophageal Squamous Cell Carcinoma
por: Chen, Tian, et al.
Publicado: (2015)

Overexpression of MUC16 predicts favourable prognosis in MUC16-mutant cervical cancer related to immune response
por: Wang, Hao, et al.
Publicado: (2020)

MUC16 promotes EOC proliferation by regulating GLUT1 expression
por: Wang, Fang, et al.
Publicado: (2021)

Kaiso Interacts with p120-Catenin to Regulate β-Catenin Expression at the Transcriptional Level
por: Liu, Yang, et al.
Publicado: (2014)

Differential Expression of MUC12, MUC16, and MUC20 in Patients with Active and Remission Ulcerative Colitis
por: Yamamoto-Furusho, Jesús K., et al.
Publicado: (2015)

Knockdown of MUC16 (CA125) Enhances the Migration and Invasion of Hepatocellular Carcinoma Cells
por: Huang, Yao, et al.
Publicado: (2021)

Functional Consequences of Differential O-glycosylation of MUC1, MUC4, and MUC16 (Downstream Effects on Signaling)
por: Hanson, Ryan L., et al.
Publicado: (2016)

p120-catenin and β-catenin differentially regulate cadherin adhesive function
por: Oas, Rebecca G., et al.
Publicado: (2013)

Therapeutic effect of dual CAR-T targeting PDL1 and MUC16 antigens on ovarian cancer cells in mice
por: Li, Tong, et al.
Publicado: (2020)

p120, a p120-related protein (p100), and the cadherin/catenin complex
Publicado: (1995)

Characterization of the MUC1-C Cytoplasmic Domain as a Cancer Target
por: Raina, Deepak, et al.
Publicado: (2015)

Concentrations of MUC16 and MUC5AC using three tear collection methods
por: Ablamowicz, Anna F., et al.
Publicado: (2017)

p120 Catenin Is Required for the Stress Response in Drosophila
por: Stefanatos, Rhoda K., et al.
Publicado: (2013)

Differential expression of p120-catenin 1 and 3 isoforms in epithelial tissues
por: Venhuizen, Jan-Hendrik, et al.
Publicado: (2019)

C-terminus of MUC16 activates Wnt signaling pathway through its interaction with β-catenin to promote tumorigenesis and metastasis
por: Liu, Qi, et al.
Publicado: (2016)

MUC16 provides immune protection by inhibiting synapse formation between NK and ovarian tumor cells
por: Gubbels, Jennifer AA, et al.
Publicado: (2010)

Carboxyl-terminal domain of MUC16 imparts tumorigenic and metastatic functions through nuclear translocation of JAK2 to pancreatic cancer cells
por: Das, Srustidhar, et al.
Publicado: (2015)

MicroRNA-16 inhibits migration and invasion via regulation of the Wnt/β-catenin signaling pathway in ovarian cancer
por: Li, Nan, et al.
Publicado: (2019)

MUC16 affects the biological functions of ovarian cancer cells and induces an antitumor immune response by activating dendritic cells
por: Zhai, Yan, et al.
Publicado: (2020)

CircMUC16 promotes autophagy of epithelial ovarian cancer via interaction with ATG13 and miR-199a
por: Gan, Xiaoling, et al.
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_as2gm63esv4k4niesc8g82kmmn