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Microdialysis in awake macaque monkeys for central nervous system pharmacokinetics
BACKGROUND: The brain bioavailability of novel small molecules developed to address central nervous system disease is classically documented through ex vivo or in vivo analyses conducted in rodent models. Data acquired in rodent models are, however, not easily transferrable to human as the pharmacok...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley and Sons Inc.
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6388052/ https://www.ncbi.nlm.nih.gov/pubmed/30891581 http://dx.doi.org/10.1002/ame2.12046 |