Microdialysis in awake macaque monkeys for central nervous system pharmacokinetics

BACKGROUND: The brain bioavailability of novel small molecules developed to address central nervous system disease is classically documented through ex vivo or in vivo analyses conducted in rodent models. Data acquired in rodent models are, however, not easily transferrable to human as the pharmacok...

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Detalles Bibliográficos
Autores principales: Thiollier, Thibaud, Wu, Caisheng, Porras, Gregory, Bezard, Erwan, Li, Qin, Zhang, Jinlan, Contamin, Hugues
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2018
Materias:
Original Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6388052/
https://www.ncbi.nlm.nih.gov/pubmed/30891581
http://dx.doi.org/10.1002/ame2.12046

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