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Evaluation of the Molecular State of Piperine in Cyclodextrin Complexes by Near-Infrared Spectroscopy and Solid-State Fluorescence Measurements

The purpose of this study was to evaluate the physicochemical properties of piperine (PP) in ground mixtures (GMs) of PP with α-, β-, or γ-cyclodextrin (CD) under conditions of humidity, heat, and humidity-heat. In solid-state fluorescence measurements, the fluorescence maxima for GM (PP/αCD = 1/2),...

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Autores principales: Ezawa, Toshinari, Inoue, Yutaka, Murata, Isamu, Takao, Koichi, Sugita, Yoshiaki, Kanamoto, Ikuo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6388355/
https://www.ncbi.nlm.nih.gov/pubmed/30886749
http://dx.doi.org/10.1155/2019/7530480
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author Ezawa, Toshinari
Inoue, Yutaka
Murata, Isamu
Takao, Koichi
Sugita, Yoshiaki
Kanamoto, Ikuo
author_facet Ezawa, Toshinari
Inoue, Yutaka
Murata, Isamu
Takao, Koichi
Sugita, Yoshiaki
Kanamoto, Ikuo
author_sort Ezawa, Toshinari
collection PubMed
description The purpose of this study was to evaluate the physicochemical properties of piperine (PP) in ground mixtures (GMs) of PP with α-, β-, or γ-cyclodextrin (CD) under conditions of humidity, heat, and humidity-heat. In solid-state fluorescence measurements, the fluorescence maxima for GM (PP/αCD = 1/2), GM (PP/βCD = 1/1), and GM (PP/γCD = 1/1) were observed at 463, 472, and 469 nm, respectively. On the other hand, the humidified GMs exhibited maxima at 454, 460, and 465 nm, while the humidified-heated samples displayed fluorescence maxima at 455, 455, and 469 nm, respectively. Therefore, the molecular behavior of PP with α, β, and γCD was concluded to vary upon the coordination of water molecules. NIR and solid-state fluorescence measurements revealed that the molecular behavior of PP inside the α, β, and γCD cavity changed by water and heat factors depends on the mobility of the methylenedioxyphenyl group.
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spelling pubmed-63883552019-03-18 Evaluation of the Molecular State of Piperine in Cyclodextrin Complexes by Near-Infrared Spectroscopy and Solid-State Fluorescence Measurements Ezawa, Toshinari Inoue, Yutaka Murata, Isamu Takao, Koichi Sugita, Yoshiaki Kanamoto, Ikuo Int J Med Chem Research Article The purpose of this study was to evaluate the physicochemical properties of piperine (PP) in ground mixtures (GMs) of PP with α-, β-, or γ-cyclodextrin (CD) under conditions of humidity, heat, and humidity-heat. In solid-state fluorescence measurements, the fluorescence maxima for GM (PP/αCD = 1/2), GM (PP/βCD = 1/1), and GM (PP/γCD = 1/1) were observed at 463, 472, and 469 nm, respectively. On the other hand, the humidified GMs exhibited maxima at 454, 460, and 465 nm, while the humidified-heated samples displayed fluorescence maxima at 455, 455, and 469 nm, respectively. Therefore, the molecular behavior of PP with α, β, and γCD was concluded to vary upon the coordination of water molecules. NIR and solid-state fluorescence measurements revealed that the molecular behavior of PP inside the α, β, and γCD cavity changed by water and heat factors depends on the mobility of the methylenedioxyphenyl group. Hindawi 2019-02-11 /pmc/articles/PMC6388355/ /pubmed/30886749 http://dx.doi.org/10.1155/2019/7530480 Text en Copyright © 2019 Toshinari Ezawa et al. https://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Ezawa, Toshinari
Inoue, Yutaka
Murata, Isamu
Takao, Koichi
Sugita, Yoshiaki
Kanamoto, Ikuo
Evaluation of the Molecular State of Piperine in Cyclodextrin Complexes by Near-Infrared Spectroscopy and Solid-State Fluorescence Measurements
title Evaluation of the Molecular State of Piperine in Cyclodextrin Complexes by Near-Infrared Spectroscopy and Solid-State Fluorescence Measurements
title_full Evaluation of the Molecular State of Piperine in Cyclodextrin Complexes by Near-Infrared Spectroscopy and Solid-State Fluorescence Measurements
title_fullStr Evaluation of the Molecular State of Piperine in Cyclodextrin Complexes by Near-Infrared Spectroscopy and Solid-State Fluorescence Measurements
title_full_unstemmed Evaluation of the Molecular State of Piperine in Cyclodextrin Complexes by Near-Infrared Spectroscopy and Solid-State Fluorescence Measurements
title_short Evaluation of the Molecular State of Piperine in Cyclodextrin Complexes by Near-Infrared Spectroscopy and Solid-State Fluorescence Measurements
title_sort evaluation of the molecular state of piperine in cyclodextrin complexes by near-infrared spectroscopy and solid-state fluorescence measurements
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6388355/
https://www.ncbi.nlm.nih.gov/pubmed/30886749
http://dx.doi.org/10.1155/2019/7530480
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