Clinical significance of polyglutamylation in primary central nervous system lymphoma

The therapeutic response to high-dose methotrexate (HD-MTX) therapy for primary central nervous system lymphoma (PCNSL) varies. Polyglutamylation is a reversible protein modification with a high occurrence rate in tumor cells. MTX incorporated into cells is polyglutamylated and strongly binds to dih...

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Detalles Bibliográficos
Autores principales: Shinojima, Naoki, Fujimoto, Kenji, Makino, Keishi, Todaka, Kohei, Yamada, Kazumichi, Mikami, Yoshiki, Oda, Kazutaka, Nakamura, Kazumi, Jono, Hirofumi, Kuratsu, Jun-ichi, Nakamura, Hideo, Yano, Shigetoshi, Mukasa, Akitake
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2018
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6389236/
https://www.ncbi.nlm.nih.gov/pubmed/29475458
http://dx.doi.org/10.1186/s40478-018-0522-4

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6389236/
https://www.ncbi.nlm.nih.gov/pubmed/29475458
http://dx.doi.org/10.1186/s40478-018-0522-4

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