Heterodimerization of UNC-13/RIM regulates synaptic vesicle release probability but not priming in C. elegans

UNC-13 proteins play an essential role in synaptic transmission by recruiting synaptic vesicles (SVs) to become available for release, which is termed SV priming. Here we show that the C2A domain of UNC-13L, like the corresponding domain in mammalian Munc13-1, displays two conserved binding modes: f...

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Detalles Bibliográficos
Autores principales: Liu, Haowen, Li, Lei, Nedelcu, Daniel, Hall, Qi, Zhou, Lijun, Wang, Wei, Yu, Yi, Kaplan, Joshua M, Hu, Zhitao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2019
Materias:
Neuroscience
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6389284/
https://www.ncbi.nlm.nih.gov/pubmed/30802206
http://dx.doi.org/10.7554/eLife.40585

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6389284/
https://www.ncbi.nlm.nih.gov/pubmed/30802206
http://dx.doi.org/10.7554/eLife.40585

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