Cargando…

Heterodimerization of UNC-13/RIM regulates synaptic vesicle release probability but not priming in C. elegans

UNC-13 proteins play an essential role in synaptic transmission by recruiting synaptic vesicles (SVs) to become available for release, which is termed SV priming. Here we show that the C2A domain of UNC-13L, like the corresponding domain in mammalian Munc13-1, displays two conserved binding modes: f...

Descripción completa

Detalles Bibliográficos
Autores principales:	Liu, Haowen, Li, Lei, Nedelcu, Daniel, Hall, Qi, Zhou, Lijun, Wang, Wei, Yu, Yi, Kaplan, Joshua M, Hu, Zhitao
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	eLife Sciences Publications, Ltd 2019
Materias:	Neuroscience
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6389284/ https://www.ncbi.nlm.nih.gov/pubmed/30802206 http://dx.doi.org/10.7554/eLife.40585

Ejemplares similares

A Hyperactive Form of unc-13 Enhances Ca(2+) Sensitivity and Synaptic Vesicle Release Probability in C. elegans
por: Li, Lei, et al.
Publicado: (2019)

Heterodimerization of Munc13 C(2)A domain with RIM regulates synaptic vesicle docking and priming
por: Camacho, Marcial, et al.
Publicado: (2017)

The M domain in UNC-13 regulates the probability of neurotransmitter release
por: Liu, Haowen, et al.
Publicado: (2021)

Position of UNC-13 in the active zone regulates synaptic vesicle release probability and release kinetics
por: Zhou, Keming, et al.
Publicado: (2013)

UNC-13L, UNC-13S, and Tomosyn form a protein code for fast and slow neurotransmitter release in Caenorhabditis elegans
por: Hu, Zhitao, et al.
Publicado: (2013)

The role of RIM in neurotransmitter release: promotion of synaptic vesicle docking, priming, and fusion
por: Wu, Shanshan, et al.
Publicado: (2023)

C. elegans Clarinet/CLA-1 recruits RIMB-1/RIM-binding protein and UNC-13 to orchestrate presynaptic neurotransmitter release
por: Krout, Mia, et al.
Publicado: (2023)

UNC-41/Stonin Functions with AP2 to Recycle Synaptic Vesicles in Caenorhabditis elegans
por: Mullen, Gregory P., et al.
Publicado: (2012)

RIM-binding protein couples synaptic vesicle recruitment to release sites
por: Petzoldt, Astrid G., et al.
Publicado: (2020)

Tomosyn Inhibits Synaptic Vesicle Priming in Caenorhabditis elegans
por: Gracheva, Elena O, et al.
Publicado: (2006)

Different priming states of synaptic vesicles underlie distinct release probabilities at hippocampal excitatory synapses
por: Aldahabi, Mohammad, et al.
Publicado: (2022)

RIM-BP2 primes synaptic vesicles via recruitment of Munc13-1 at hippocampal mossy fiber synapses
por: Brockmann, Marisa M, et al.
Publicado: (2019)

Disentangling the Roles of RIM and Munc13 in Synaptic Vesicle Localization and Neurotransmission
por: Zarebidaki, Fereshteh, et al.
Publicado: (2020)

UNC-43/CaMKII-triggered anterograde signals recruit GABA(A)Rs to mediate inhibitory synaptic transmission and plasticity at C. elegans NMJs
por: Hao, Yue, et al.
Publicado: (2023)

Prion protein facilitates synaptic vesicle release by enhancing release probability
por: Robinson, Susan W., et al.
Publicado: (2014)

RIM1α SUMOylation Is Required for Fast Synaptic Vesicle Exocytosis
por: Girach, Fatima, et al.
Publicado: (2013)

Intersectin and Endophilin condensates prime synaptic vesicles for release site replenishment
por: Ogunmowo, Tyler, et al.
Publicado: (2023)

Molecular Machines Regulating the Release Probability of Synaptic Vesicles at the Active Zone
por: Körber, Christoph, et al.
Publicado: (2016)

Differential Regulation of Synaptic Vesicle Tethering and Docking by UNC-18 and TOM-1
por: Gracheva, Elena O., et al.
Publicado: (2010)

Deconstructing Synaptotagmin-1's Distinct Roles in Synaptic Vesicle Priming and Neurotransmitter Release
por: Bouazza-Arostegui, Boris, et al.
Publicado: (2022)

Fife organizes synaptic vesicles and calcium channels for high-probability neurotransmitter release
por: Bruckner, Joseph J., et al.
Publicado: (2017)

Elevated synaptic vesicle release probability in synaptophysin/gyrin family quadruple knockouts
por: Raja, Mathan K, et al.
Publicado: (2019)

Control of synaptic vesicle release probability via VAMP4 targeting to endolysosomes
por: Ivanova, Daniela, et al.
Publicado: (2021)

RIM-Binding Protein 2 Organizes Ca(2+) Channel Topography and Regulates Release Probability and Vesicle Replenishment at a Fast Central Synapse
por: Butola, Tanvi, et al.
Publicado: (2021)

Roles for diacylglycerol in synaptic vesicle priming and release revealed by complete reconstitution of core protein machinery
por: Kalyana Sundaram, R. Venkat, et al.
Publicado: (2023)

Endogenous expression of UNC-59/Septin in C. elegans
por: Chen, David D., et al.
Publicado: (2019)

The Small and Dynamic Pre-primed Pool at the Release Site; A Useful Concept to Understand Release Probability and Short-Term Synaptic Plasticity?
por: Gustafsson, Bengt, et al.
Publicado: (2019)

Cryo–electron tomography reveals a critical role of RIM1α in synaptic vesicle tethering
por: Fernández-Busnadiego, Rubén, et al.
Publicado: (2013)

Novel Roles for Diacylglycerol in Synaptic Vesicle Priming and Release Revealed by Complete Reconstitution of Core Protein Machinery
por: Sundaram, R Venkat Kalyana, et al.
Publicado: (2023)

Identifying the prime suspects in vesicle release
por: Short, Ben
Publicado: (2010)

Male pheromones modulate synaptic transmission at the C. elegans neuromuscular junction in a sexually dimorphic manner
por: Qian, Kang-Ying, et al.
Publicado: (2021)

Fast Cerebellar Reflex Circuitry Requires Synaptic Vesicle Priming by Munc13-3
por: Netrakanti, Pallavi Rao, et al.
Publicado: (2015)

Large Isoforms of UNC-89 (Obscurin) Are Required for Muscle Cell Architecture and Optimal Calcium Release in Caenorhabditis elegans
por: Spooner, Patrick M., et al.
Publicado: (2012)

Modulating organelle distribution using light-inducible heterodimerization in C. elegans
por: Dansen, Tobias B., et al.
Publicado: (2021)

Bruchpilot readies synaptic vesicles for release
por: Short, Ben
Publicado: (2013)

Clearing the way for synaptic vesicle release
por: Sedwick, Caitlin
Publicado: (2018)

UNC-108/RAB-2 and its effector RIC-19 are involved in dense core vesicle maturation in Caenorhabditis elegans
por: Sumakovic, Marija, et al.
Publicado: (2009)

Selecting synaptic partners: GRASPing the role of UNC-6/netrin
por: Ch'ng, QueeLim
Publicado: (2011)

A Novel Role for UNC119 as an Enhancer of Synaptic Transmission
por: Fehlhaber, Katherine E., et al.
Publicado: (2023)

Presynaptic Rac1 controls synaptic strength through the regulation of synaptic vesicle priming
por: Keine, Christian, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_st6kllgt9gtkjqp1ussh5mvr9a