Cargando…
The Impact and Mechanism of a Novel Allosteric AMPA Receptor Modulator LCX001 on Protection Against Respiratory Depression in Rodents
Analgesics and sedative hypnotics in clinical use often give rise to significant side effects, particularly respiratory depression. For emergency use, specific antagonists are currently administered to counteract respiratory depression. However, antagonists are often short-lasting and eliminate drug...
Autores principales: | Dai, Wei, Gao, Xiang, Xiao, Dian, Li, Yu-Lei, Zhou, Xin-Bo, Yong, Zheng, Su, Rui-Bin |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2019
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6389625/ https://www.ncbi.nlm.nih.gov/pubmed/30837875 http://dx.doi.org/10.3389/fphar.2019.00105 |
Ejemplares similares
-
Design, Synthesis and Biological Evaluation of Brain-Targeted Thiamine Disulfide Prodrugs of Ampakine Compound LCX001
por: Xiao, Dian, et al.
Publicado: (2016) -
Are AMPA Receptor Positive Allosteric Modulators Potential Pharmacotherapeutics for Addiction?
por: Watterson, Lucas R., et al.
Publicado: (2013) -
Role of Stoichiometry in the Dimer-Stabilizing Effect
of AMPA Receptor Allosteric Modulators
por: Ptak, Christopher P., et al.
Publicado: (2013) -
Affecting AMPA Receptor Biophysical Gating Properties with Negative Allosteric Modulators
por: Qneibi, Mohammad, et al.
Publicado: (2022) -
GABA Receptor Agonists Protect From Excitotoxic Damage Induced by AMPA in Oligodendrocytes
por: Bayón-Cordero, Laura, et al.
Publicado: (2022)