Requirement for Cyclic AMP/Protein Kinase A-Dependent Canonical NFκB Signaling in the Adjuvant Action of Cholera Toxin and Its Non-toxic Derivative mmCT

Cholera toxin (CT) is widely used as an effective adjuvant in experimental immunology for inducing mucosal immune responses; yet its mechanisms of adjuvant action remain incompletely defined. Here, we demonstrate that mice lacking NFκB, compared to wild-type (WT) mice, had a 90% reduction in their s...

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Detalles Bibliográficos
Autores principales: Terrinoni, Manuela, Holmgren, Jan, Lebens, Michael, Larena, Maximilian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2019
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6389712/
https://www.ncbi.nlm.nih.gov/pubmed/30838003
http://dx.doi.org/10.3389/fimmu.2019.00269

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6389712/
https://www.ncbi.nlm.nih.gov/pubmed/30838003
http://dx.doi.org/10.3389/fimmu.2019.00269

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