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Carbon Acidity in Enzyme Active Sites

The pK(a) values for substrates acting as carbon acids (i.e., C-H deprotonation reactions) in several enzyme active sites are presented. The information needed to calculate them includes the pK(a) of the active site acid/base catalyst and the equilibrium constant for the deprotonation step. Carbon a...

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Detalles Bibliográficos
Autor principal: Toney, Michael D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6389717/
https://www.ncbi.nlm.nih.gov/pubmed/30838206
http://dx.doi.org/10.3389/fbioe.2019.00025