Cellular TRIM33 restrains HIV-1 infection by targeting viral integrase for proteasomal degradation

Productive HIV-1 replication requires viral integrase (IN), which catalyzes integration of the viral genome into the host cell DNA. IN, however, is short lived and is rapidly degraded by the host ubiquitin-proteasome system. To identify the cellular factors responsible for HIV-1 IN degradation, we p...

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Detalles Bibliográficos
Autores principales: Ali, Hashim, Mano, Miguel, Braga, Luca, Naseem, Asma, Marini, Bruna, Vu, Diem My, Collesi, Chiara, Meroni, Germana, Lusic, Marina, Giacca, Mauro
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6389893/
https://www.ncbi.nlm.nih.gov/pubmed/30804369
http://dx.doi.org/10.1038/s41467-019-08810-0

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6389893/
https://www.ncbi.nlm.nih.gov/pubmed/30804369
http://dx.doi.org/10.1038/s41467-019-08810-0

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