Cargando…
Cellular TRIM33 restrains HIV-1 infection by targeting viral integrase for proteasomal degradation
Productive HIV-1 replication requires viral integrase (IN), which catalyzes integration of the viral genome into the host cell DNA. IN, however, is short lived and is rapidly degraded by the host ubiquitin-proteasome system. To identify the cellular factors responsible for HIV-1 IN degradation, we p...
| Autores principales: | , , , , , , , , , |
|---|---|
| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Nature Publishing Group UK
2019
|
| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6389893/ https://www.ncbi.nlm.nih.gov/pubmed/30804369 http://dx.doi.org/10.1038/s41467-019-08810-0 |