Cargando…
Assembly and functionality of the ribosome with tethered subunits
Ribo-T is an engineered ribosome whose small and large subunits are tethered together by linking 16S rRNA and 23S rRNA in a single molecule. Although Ribo-T can support cell proliferation in the absence of wild type ribosomes, Ribo-T cells grow slower than those with wild type ribosomes. Here, we sh...
Autores principales: | Aleksashin, Nikolay A., Leppik, Margus, Hockenberry, Adam J., Klepacki, Dorota, Vázquez-Laslop, Nora, Jewett, Michael C., Remme, Jaanus, Mankin, Alexander S. |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2019
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6389949/ https://www.ncbi.nlm.nih.gov/pubmed/30804338 http://dx.doi.org/10.1038/s41467-019-08892-w |
Ejemplares similares
-
Ribosome engineering reveals the importance of 5S rRNA autonomy for ribosome assembly
por: Huang, Shijie, et al.
Publicado: (2020) -
The context of the ribosome binding site in mRNAs defines specificity of action of kasugamycin, an inhibitor of translation initiation
por: Zhang, Yan, et al.
Publicado: (2022) -
Random pseuoduridylation in vivo reveals critical region of Escherichia coli 23S rRNA for ribosome assembly
por: Leppik, Margus, et al.
Publicado: (2017) -
Nascent peptide assists the ribosome in recognizing chemically distinct small molecules
por: Gupta, Pulkit, et al.
Publicado: (2016) -
Engineered ribosomes with tethered subunits for expanding biological function
por: Carlson, Erik D., et al.
Publicado: (2019)