Precisely controlling endogenous protein dosage in hPSCs and derivatives to model FOXG1 syndrome

Dosage of key regulators impinge on developmental disorders such as FOXG1 syndrome. Since neither knock-out nor knock-down strategy assures flexible and precise protein abundance control, to study hypomorphic or haploinsufficiency expression remains challenging. We develop a system in human pluripot...

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Detalles Bibliográficos
Autores principales: Zhu, Wenliang, Zhang, Boya, Li, Mengqi, Mo, Fan, Mi, Tingwei, Wu, Yihui, Teng, Zhaoqian, Zhou, Qi, Li, Wei, Hu, Baoyang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6389984/
https://www.ncbi.nlm.nih.gov/pubmed/30804331
http://dx.doi.org/10.1038/s41467-019-08841-7

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6389984/
https://www.ncbi.nlm.nih.gov/pubmed/30804331
http://dx.doi.org/10.1038/s41467-019-08841-7

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