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Precisely controlling endogenous protein dosage in hPSCs and derivatives to model FOXG1 syndrome
Dosage of key regulators impinge on developmental disorders such as FOXG1 syndrome. Since neither knock-out nor knock-down strategy assures flexible and precise protein abundance control, to study hypomorphic or haploinsufficiency expression remains challenging. We develop a system in human pluripot...
| Autores principales: | , , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Nature Publishing Group UK
2019
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6389984/ https://www.ncbi.nlm.nih.gov/pubmed/30804331 http://dx.doi.org/10.1038/s41467-019-08841-7 |