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Insulin ameliorates pulmonary edema through the upregulation of epithelial sodium channel via the PI3K/SGK1 pathway in mice with lipopolysaccharide-induced lung injury
Epithelial sodium channel (ENaC) provides the driving force for the removal of edema from the alveolar spaces in acute lung injury (ALI). Our previous study reported that insulin increased the expression of α-ENaC, possibly via the serum/glucocorticoid-inducible kinase-1 (SGK1) pathway in ALI; howev...
Autores principales: | Deng, Wang, Li, Chang-Yi, Tong, Jin, He, Jing, Zhao, Yan, Wang, Dao-Xin |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
D.A. Spandidos
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6390057/ https://www.ncbi.nlm.nih.gov/pubmed/30628684 http://dx.doi.org/10.3892/mmr.2019.9809 |
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