Cargando…

HIF-1 transcription activity: HIF1A driven response in normoxia and in hypoxia

BACKGROUND: HIF1A (Hypoxia-Inducible-Factor 1A) expression in solid tumors is relevant to establish resistance to therapeutic approaches. The use of compounds direct against hypoxia signaling and HIF1A does not show clinical efficiency because of changeable oxygen concentrations in solid tumor areas...

Descripción completa

Detalles Bibliográficos
Autores principales:	Cimmino, Flora, Avitabile, Marianna, Lasorsa, Vito Alessandro, Montella, Annalaura, Pezone, Lucia, Cantalupo, Sueva, Visconte, Feliciano, Corrias, Maria Valeria, Iolascon, Achille, Capasso, Mario
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2019
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6390360/ https://www.ncbi.nlm.nih.gov/pubmed/30808328 http://dx.doi.org/10.1186/s12881-019-0767-1

Ejemplares similares

Functional characterization of full-length BARD1 strengthens its role as a tumor suppressor in neuroblastoma
por: Cimmino, Flora, et al.
Publicado: (2020)

FGFR1 is a potential therapeutic target in neuroblastoma
por: Cimmino, Flora, et al.
Publicado: (2022)

Association of PARP1 polymorphisms with response to chemotherapy in patients with high‐risk neuroblastoma
por: Avitabile, Marianna, et al.
Publicado: (2020)

CFDP1 is a neuroblastoma susceptibility gene that regulates transcription factors of the noradrenergic cell identity
por: Formicola, Daniela, et al.
Publicado: (2022)

Genetic Predisposition to Solid Pediatric Cancers
por: Capasso, Mario, et al.
Publicado: (2020)

Inhibition of hypoxia inducible factors combined with all-trans retinoic acid treatment enhances glial transdifferentiation of neuroblastoma cells
por: Cimmino, Flora, et al.
Publicado: (2015)

CD55 is a HIF-2α marker with anti-adhesive and pro-invading properties in neuroblastoma
por: Cimmino, F, et al.
Publicado: (2016)

Single-cell transcriptomics of neuroblastoma identifies chemoresistance-associated genes and pathways
por: Avitabile, Marianna, et al.
Publicado: (2022)

Exploring Shared Susceptibility between Two Neural Crest Cells Originating Conditions: Neuroblastoma and Congenital Heart Disease
por: Testori, Alessandro, et al.
Publicado: (2019)

Effects of 2-methoxyestradiol on apoptosis and HIF-1α and HIF-2α expression in lung cancer cells under normoxia and hypoxia
por: AQUINO-GÁLVEZ, ARNOLDO, et al.
Publicado: (2016)

A Targeted Gene Panel for Circulating Tumor DNA Sequencing in Neuroblastoma
por: Cimmino, Flora, et al.
Publicado: (2020)

Stain-free identification of cell nuclei using tomographic phase microscopy in flow cytometry
por: Pirone, Daniele, et al.
Publicado: (2022)

The HIF1α-PDGFD-PDGFRα axis controls glioblastoma growth at normoxia/mild-hypoxia and confers sensitivity to targeted therapy by echinomycin
por: Peng, Gong, et al.
Publicado: (2021)

Raised HIF1α during normoxia in high altitude pulmonary edema susceptible non-mountaineers
por: Soree, Poonam, et al.
Publicado: (2016)

Overexpression of bHLH domain of HIF-1 failed to inhibit the HIF-1 transcriptional activity in hypoxia
por: Sadeghi, Fatemeh, et al.
Publicado: (2020)

Cigarette smoke causes a bioenergetic crisis in RPE cells involving the downregulation of HIF-1α under normoxia
por: Henning, Yoshiyuki, et al.
Publicado: (2023)

19p loss is significantly enriched in older age neuroblastoma patients and correlates with poor prognosis
por: Lasorsa, Vito Alessandro, et al.
Publicado: (2020)

The Importance of Hypoxia-Inducible Factors (HIF-1 and HIF-2) for the Pathophysiology of Inflammatory Bowel Disease
por: Kerber, Evelyn L., et al.
Publicado: (2020)

Inherited rare variants in homologous recombination and neurodevelopmental genes are associated with increased risk of neuroblastoma
por: Bonfiglio, Ferdinando, et al.
Publicado: (2022)

The transition from HIF-1 to HIF-2 during prolonged hypoxia results from reactivation of PHDs and HIF1A mRNA instability
por: Jaśkiewicz, Maciej, et al.
Publicado: (2022)

HIF1α stabilization in hypoxia is not oxidant-initiated
por: Kumar, Amit, et al.
Publicado: (2021)

Genetic Analysis of the Coronavirus SARS-CoV-2 Host Protease TMPRSS2 in Different Populations
por: Russo, Roberta, et al.
Publicado: (2020)

Cancer Cell Metabolism in Hypoxia: Role of HIF-1 as Key Regulator and Therapeutic Target
por: Infantino, Vittoria, et al.
Publicado: (2021)

HIF repressors under chronic hypoxia
por: Luo, Weibo, et al.
Publicado: (2016)

Hypoxia/HIF Modulates Immune Responses
por: Chen, Yuling, et al.
Publicado: (2021)

Regulation of chromatin accessibility by hypoxia and HIF
por: Batie, Michael, et al.
Publicado: (2022)

Dysregulation of hypoxia-inducible factor-1α (Hif1α) expression in the Hmox1-deficient placenta
por: Zhao, Hui, et al.
Publicado: (2020)

Characterization and functional analysis of hypoxia-inducible factor HIF1α and its inhibitor HIF1αn in tilapia
por: Li, Hong Lian, et al.
Publicado: (2017)

Association of Age with the Expression of Hypoxia-Inducible Factors HIF-1α, HIF-2α, HIF-3α and VEGF in Lung and Heart of Tibetan Sheep
por: He, Yanyu, et al.
Publicado: (2019)

KDM2 Family Members are Regulated by HIF-1 in Hypoxia
por: Batie, Michael, et al.
Publicado: (2017)

Hypoxia-Inducible Factor-1 (Hif-1) in Experimental Brain Ischemia
por: Schmidt-Kastner, Rainald, et al.
Publicado: (2002)

Common variants at 21q22.3 locus influence MX1 and TMPRSS2 gene expression and susceptibility to severe COVID-19
por: Andolfo, Immacolata, et al.
Publicado: (2021)

Stable knockdown of CREB, HIF-1 and HIF-2 by replication-competent retroviruses abrogates the responses to hypoxia in hepatocellular carcinoma
por: Shneor, D, et al.
Publicado: (2017)

HIF-2α, but not HIF-1α, mediates hypoxia-induced up-regulation of Flt-1 gene expression in placental trophoblasts
por: Sasagawa, Tadashi, et al.
Publicado: (2018)

L3MBTL3 is induced by HIF-1α and fine tunes the HIF-1α degradation under hypoxia in vitro
por: Wang, Mengdong, et al.
Publicado: (2023)

VBP1 negatively regulates CHIP and selectively inhibits the activity of hypoxia-inducible factor (HIF)-1α but not HIF-2α
por: Yue, Yiming, et al.
Publicado: (2023)

Genome-wide Association of Hypoxia-inducible Factor (HIF)-1α and HIF-2α DNA Binding with Expression Profiling of Hypoxia-inducible Transcripts
por: Mole, David R., et al.
Publicado: (2009)

An 18 gene expression-based score classifier predicts the clinical outcome in stage 4 neuroblastoma
por: Formicola, Daniela, et al.
Publicado: (2016)

Nuclear FGFR2 negatively regulates hypoxia-induced cell invasion in prostate cancer by interacting with HIF-1 and HIF-2
por: Lee, Jae Eun, et al.
Publicado: (2019)

Distinct roles for the hypoxia-inducible transcription factors HIF-1α and HIF-2α in human osteoclast formation and function
por: Knowles, Helen J.
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_mkmpo1fuk2khoj4r7cmu730juf