Cardiomyocyte SMAD4-Dependent TGF-β Signaling is Essential to Maintain Adult Heart Homeostasis

The role of the transforming growth factor (TGF)-β pathway in myocardial fibrosis is well recognized. However, the precise role of this signaling axis in cardiomyocyte (CM) biology is not defined. In TGF-β signaling, SMAD4 acts as the central intracellular mediator. To investigate the role of TGF-β...

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Detalles Bibliográficos
Autores principales: Umbarkar, Prachi, Singh, Anand P., Gupte, Manisha, Verma, Vipin K., Galindo, Cristi L., Guo, Yuanjun, Zhang, Qinkun, McNamara, James W., Force, Thomas, Lal, Hind
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2019
Materias:
PRECLINICAL RESEARCH
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6390466/
https://www.ncbi.nlm.nih.gov/pubmed/30847418
http://dx.doi.org/10.1016/j.jacbts.2018.10.003

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6390466/
https://www.ncbi.nlm.nih.gov/pubmed/30847418
http://dx.doi.org/10.1016/j.jacbts.2018.10.003

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